R428, CAS [[1037624-75-1]]

Produktübersicht

• Artikelname: R428, CAS [[1037624-75-1]]
• Artikelnummer: FBM-10-4676
• Hersteller Artikelnummer: 10-4676
• Alternativnummer: FBM-10-4676-5MG, FBM-10-4676-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-(3,4-Diazatricyclo[9.4.0.02,7]pentadeca-1(15),2,4,6,11,13-hexaen-5-yl)-3-N-[(7S)-7-pyrrolidin-1-yl-6,7,8,9-tetrahydro-5H-benzo[7]annulen-3-yl]-1,2,4-triazole-3,5-diamine. Alternate Names: Bemcentinib, BGB324

Produktbeschreibung

AXL inhibitor

Produkteigenschaften

• Molekulargewicht: 506.64
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [1037624-75-1]
• Formel: C30H34N8

Anwendungsbeschreibung

• Anwendungsbeschreibung: R428 (1037624-75-1) is a potent and selective inhibitor of AXL kinase (IC50 = 1.4nM).1 R428 has been shown to overcome chemotherapy resistance to various agents in multiple cancer models.2-5 AXL has been shown to suppress myeloid cell activation and function - combined AXL inhibition with R428 and PD-1 blockade showed potent synergistic antitumor effects.6,7