JH-X-119-01, CAS [[2227368-54-7]]

Produktübersicht

• Artikelname: JH-X-119-01, CAS [[2227368-54-7]]
• Artikelnummer: FBM-10-4691
• Hersteller Artikelnummer: 10-4691
• Alternativnummer: FBM-10-4691-5MG,FBM-10-4691-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: N-[4-[[3-(Prop-2-enoylamino)benzoyl]amino]phenyl]-6-(1H-pyrazol-5-yl)pyridine-2-carboxamide

Produktbeschreibung

Selective IRAK1 inhibitor

Produkteigenschaften

• Molekulargewicht: 452.47
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [2227368-54-7]
• Formel: C25H20N6O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: JH-X-119-01 is a highly selective (significantly inhibited only YSK4 and MEK3 in a panel of over 300 kinases) and potent (IC50 = 9 nM) covalent inhibitor of interleukin 1 receptor-associated kinase 1 (IRAK1). It displayed cytotoxic activity against several lymphoma cell lines and exhibited synergism with the BTK inhibitor Ibrutinib in the same systems. JH-X-119-01 protected mice from LPS-induced sepsis2 and ameliorated acute graft-versus-host disease in mice undergoing allogenic hematopoietic cell transplantation without effecting the anti-lymphoma effect3.