GSK8612, CAS [[2361659-62-1]]

Produktübersicht

• Artikelname: GSK8612, CAS [[2361659-62-1]]
• Artikelnummer: FBM-10-4693
• Hersteller Artikelnummer: 10-4693
• Alternativnummer: FBM-10-4693-5MG, FBM-10-4693-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 4-[[[5-Bromo-2-[[3-methyl-1-(2,2,2-trifluoroethyl)pyrazol-4-yl]amino]pyrimidin-4-yl]amino]methyl]benzenesulfonamide

Produktbeschreibung

Highly selective TBK1 inhibitor

Produkteigenschaften

• Molekulargewicht: 520.33
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Beige solid
• CAS Nummer: [2361659-62-1]
• Formel: C17H17BrF3N7O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Highly selective and potent (avg. pIC50 = 6.8 versus recombinant TBK1) inhibitor of Tank-binding Kinase-1 (TBK1) with higher affinity for unactivated TBK1. It inhibited phosphorylation of IRF3 (pIC50 = 6.0), inhibited the release of IFNa from human PBMCs (pIC50 = 6.1), and inhibited IFNb secretion from THP-1 cells (pIC50 = 5.8 dsDNA virus, 6.3 cGAMP stilmulated cells).