BAY-876, CAS [[1799753-84-6]]

Produktübersicht

• Artikelname: BAY-876, CAS [[1799753-84-6]]
• Artikelnummer: FBM-10-4708
• Hersteller Artikelnummer: 10-4708
• Alternativnummer: FBM-10-4708-5MG,FBM-10-4708-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: 4-N-[1-[(4-Cyanophenyl)methyl]-5-methyl-3-(trifluoromethyl)pyrazol-4-yl]-7-fluoroquinoline-2,4-dicarboxamide

Produktbeschreibung

GLUT1 inhibitor

Produkteigenschaften

• Molekulargewicht: 496.43
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1799753-84-6]
• Formel: C24H16F4N6O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent inhibitor (IC50 = 2 nM) of the facilitative glucose transporter GLUT1, an enzyme frequently overexpressed in many cancers.1 It shows greater than 100-fold selectivity over GLUT2-4. BAY-876 displayed potent antitumor activity in ovarian cancer xenograft models2 and in triple negative breast cancer cells displaying high glycolytic and low oxidative phosphorylation rates3. It reduced CD4+ T cell proliferation and IFN-gamma secretion via GLUT1 inhibition suggesting utility against auto-inflammatory diseases.4 BAY-876 induces disulfidptosis in SLCA11high cancer cells.5