GSK2334470, CAS [[1227911-45-6]]

Produktübersicht

• Artikelname: GSK2334470, CAS [[1227911-45-6]]
• Artikelnummer: FBM-10-4725
• Hersteller Artikelnummer: 10-4725
• Alternativnummer: FBM-10-4725-5MG, FBM-10-4725-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (3S,6R)-1-[6-(3-Amino-1H-indazol-6-yl)-2-(methylamino)-4-pyrimidinyl]-N-cyclohexyl-6-methyl-3-piperidinecarboxamide. Alternate Names: GSK-470

Produktbeschreibung

Potent and selective PDK1 inhibitor

Produkteigenschaften

• Molekulargewicht: 462.60
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [1227911-45-6]
• Formel: C25H34N8O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent (IC50 = 10 nM) and selective inhibitor of 3-Phosphoinositide-dependent kinase 1 (PDK1), which phosphorylates and activates a group of protein kinases in the AGC/PKG/PKC family.1 It is more effective at inhibiting PDK1 substrates that are activated in the cytosol rather than at the plasma membrane.1 GSK2334470 delayed melanogenesis and metastasis in Braf(V600E)::Pten(-/-) mice.2 It also displays antitumor activity against multiple myeloma synergistically with mTORC1/2 inhibitor PP2423 and proteasome inhibitor MG-1324.