GSK583, CAS [[1346547-00-9]]

Produktübersicht

• Artikelname: GSK583, CAS [[1346547-00-9]]
• Artikelnummer: FBM-10-4761
• Hersteller Artikelnummer: 10-4761
• Alternativnummer: FBM-10-4761-10MG, FBM-10-4761-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 6-tert-Butylsulfonyl-N-(5-fluoro-1H-indazol-3-yl)quinoline-4-amine

Produktbeschreibung

RIP2 kinase inhibitor

Produkteigenschaften

• Molekulargewicht: 398.45
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Pale yellow solid
• CAS Nummer: [1346547-00-9]
• Formel: C20H19FN4O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: GSK583 is a highly selective and potent inhibitor of RIP2 kinase, IC50 = 5 nM human and IC50 = 2 nM rat.1 It also potently Inhibits isolated RPI3 kinase (IC50 = 5 nM) but is inactive against RIP3 in cellular assays due to a very low KM,ATP. GSK583 blocks NOD2 signaling by interfering with XIAP-RIP2 binding resulting in decreased cytokine and chemokine production.1,2