BMS-309403, CAS [[300657-03-8]]

Produktübersicht

• Artikelname: BMS-309403, CAS [[300657-03-8]]
• Artikelnummer: FBM-10-4762
• Hersteller Artikelnummer: 10-4762
• Alternativnummer: FBM-10-4762-5MG, FBM-10-4762-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-[3-[2-(5-Ethyl-3,4-diphenylpyrazol-1-yl)phenyl]phenoxy]acetic acid

Produktbeschreibung

FABP4 inhibitor

Produkteigenschaften

• Molekulargewicht: 474.55
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white or pale yellow solid
• CAS Nummer: [300657-03-8]
• Formel: C31H26N2O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: BMS-309403 is a potent (Ki <2 nM FABP4, Ki = 250 nM FABP3, Ki = 350 nM FABP5) and selective inhibitor of the fatty-acid-binding protein aP2 (FABP4).1,2 It demonstrated marked reductions in atherosclerotic lesions in an Apoe-/- mouse model and improved glucose metabolism, reduced inflammation, and increased insulin sensitivity in a Lepob/ob mouse model. BMS-309403 stimulated glucose uptake in myotubes via activation of AMPK.3 It decreased ER stress-associated inflammation in skeletal muscle4 and suppressed inflammation and oxidative stress in mouse and cell models of acute lung injury5.