Nobiletin is a natural product isolated from citrus peels. It has recently been shown to possess circadian clock amplitude-enhancing properties and was able to prevent metabolic syndrome in mice via a Clock gene-dependent mechanism.1 Nobiletin directly bound to and activated RORalpha/gamma. Nobiletin has previously been shown to attenuate the effects of metabolic syndrome2, have anti-neuroinflammatory effects3, possess neurotrophic activity4, and be a cancer chemopreventative agent5.
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