LDN-193189 HCl, CAS [[1435934-00-1]]

Produktübersicht

• Artikelname: LDN-193189 HCl, CAS [[1435934-00-1]]
• Artikelnummer: FBM-10-4764
• Hersteller Artikelnummer: 10-4764
• Alternativnummer: FBM-10-4764-5MG,FBM-10-4764-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: DM-3189

Produktbeschreibung

ALK2 / ALK3 inhibitor

Produkteigenschaften

• Molekulargewicht: 479.40
• Reinheit: 99% by HPLC (Agilent Poroshell 120 C18, 80/20 MeOH/water with 0.05% TFA, 0.8 ml/min) NMR (Conforms)
• Formulierung: Orange-yellow solid
• CAS Nummer: [1435934-00-1]
• Formel: C25H22N62HCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: LDN-193189 2HCl is a potent and selective inhibitor of ALK2 (IC50 = 5 nM) and ALK3 (IC50 = 30 nM), thereby inhibiting SMAD1/5/8 phosphorylation.1 Only weak inhibition of ALK4, ALK5, and ALK7 is observed. Promotes neuronal differentiation of human pluripotent stem cells.2-3 LDN-193189 HCl has also been used to examine the role of osteogenesis in prostate tumor metastases in bone.4