AZD1208, CAS [[1204144-28-4]]

Produktübersicht

• Artikelname: AZD1208, CAS [[1204144-28-4]]
• Artikelnummer: FBM-10-4781
• Hersteller Artikelnummer: 10-4781
• Alternativnummer: FBM-10-4781-5MG, FBM-10-4781-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (5Z)-5-[[2-[(3R)-3-Aminopiperidin-1-yl]-3-phenylphenyl]methylidene]-1,3-thiazolidine-2,4-dione

Produktbeschreibung

pan-PIM kinase inhibitor

Produkteigenschaften

• Molekulargewicht: 379.48
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [1204144-28-4]
• Formel: C21H21N3O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: AZD1208 is a highly selective and potent pan-PIM kinase inhibitor (IC50 = 3 nM PIM1, 150 nM PIM2, 9 nM PIM3).1 Displayed efficacy in models of acute myeloid leukemia2, prostate cancer3, and triple-negative breast cancer4. Combination treatment of AZD1208 and imatinib eliminated chronic myelogenous leukemia stem cells in cell culture and a patient-derived mouse xenograft model.5 It improved immunotherapeutic antitumor T-cell response6 and disrupted the myeloid cell-mediated immunosuppressive tumor microenvironment increasing T-cell-mediated antitumor immunity.