MTX-531, CAS [[2791417-66-6]]

Produktübersicht

• Artikelname: MTX-531, CAS [[2791417-66-6]]
• Artikelnummer: FBM-10-4802
• Hersteller Artikelnummer: 10-4802
• Alternativnummer: FBM-10-4802-5MG, FBM-10-4802-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (R)-N-(2-Chloro-5-(4-((1-phenylethyl)amino)quinazolin-6-yl)pyridine-3-yl)methanesulfonamide

Produktbeschreibung

Dual EGFR/PI3K inhibitor

Produkteigenschaften

• Molekulargewicht: 453.95
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [2791417-66-6]
• Formel: C22H20ClN5O2S

Anwendungsbeschreibung

• Anwendungsbeschreibung: MTX-531 is a first-in-class dual EGFR/pan-PI3K inhibitor (IC50s: EGFR = 14.7 nM, PI3kalpha = 6.4 nM, PI3Kß = 233 nM, PI3Kgamma = 8.3 nM, PI3Kdelta = 1.1 nM, mTOR = 105 nM, DNA-PK = 5.4 nM). MTX-531 displayed exquisite selectivity for EGFR and PI3K family members (against >400 protein/lipid kinases). It displayed efficacy in the treatment of head and neck squamous cell carcinomas and in combination with RAS inhibitors in BRAF-mutant and KRAS-mutant colorectal and pancreatic cancers. Additionally, it did not produce a hyperglycemic response that is typical for PI3K inhibitors. An interesting new chemical tool for cancer research that targets two key resistance drivers.