Silmitasertib, CAS [[1009820-21-6]]

Produktübersicht

• Artikelname: Silmitasertib, CAS [[1009820-21-6]]
• Artikelnummer: FBM-10-4809
• Hersteller Artikelnummer: 10-4809
• Alternativnummer: FBM-10-4809-5MG, FBM-10-4809-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 5-[(3-Chlorophenyl)amino]-benzo[c]-2,6-naphthyridine-8-carboxylic acid. Alternate Names: CX-4945

Produktbeschreibung

CK2 inhibitor

Produkteigenschaften

• Molekulargewicht: 349.77
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Beige solid
• CAS Nummer: [1009820-21-6]
• Formel: C19H12ClN3O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Silmitasertib is a potent and orally bioavailable inhibitor of casein kinase 2 (Ki=0.38 nM) acting at the ATP-binding site.1 It has been in preclinical and clinical development for a variety of cancers.2 It inhibits CK2-mediated phosphorylation of the SALL2 tumor suppressor preventing its proteasomal degradation and induces cell death in a variety of tumor cell lines.3 It inhibits fibroblast-like synoviocytes reducing rheumatoid arthritis disease severity in rodent models4 and inhibits collagen degradation5.