Idelalisib, CAS [[870281-82-6]]

Produktübersicht

• Artikelname: Idelalisib, CAS [[870281-82-6]]
• Artikelnummer: FBM-10-4820
• Hersteller Artikelnummer: 10-4820
• Alternativnummer: FBM-10-4820-10MG,FBM-10-4820-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Selective PI3Kdelta inhibitor

Produkteigenschaften

• Molekulargewicht: 415.43
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [870281-82-6]
• Formel: C21H18FN7O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent (IC50 = 2.5nM) and selective (IC50s: PI3Ka = 820nM, PI3Kb = 565nM, PI3Kg = 89nM) PI3Kd inhibitor.1,2 Useful clinical agent for the treatment of various blood cancers. Idelalisib attenuates regulatory T cells (Treg) but not conventional T cells (Tconv) resulting in a significant increase in tumor-infiltrating antigen-specific CD8 T cells in a murine lung cancer model.3 Conversely, systemic PI3Kd inactivation antagonized anti-CTLA-4 and anti-PD-L1 treatment.4 Others have found that Idelalisib minimally influenced rituximab- and obinutuzumab-mediated Ab-dependent cellular cytotoxicity in human lymphoma cells.5