Pexidartinib, CAS [[1029044-16-3]]

Produktübersicht

• Artikelname: Pexidartinib, CAS [[1029044-16-3]]
• Artikelnummer: FBM-10-4829
• Hersteller Artikelnummer: 10-4829
• Alternativnummer: FBM-10-4829-5MG, FBM-10-4829-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 5-[(5-Chloro-1H-pyrrolo[2,3.b]pyridine-3-yl)methyl]-N-[[6-(trifluoromethyl)pyridin-3-yl]methyl]pyridin-2-amine. Alternate Names: PLX3397

Produktbeschreibung

CSF1R inhibitor

Produkteigenschaften

• Molekulargewicht: 417.81
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1029044-16-3]
• Formel: C20H15ClF3N5

Anwendungsbeschreibung

• Anwendungsbeschreibung: Pexidartinib (1029044-16-3) is a potent and selective dual inhibitor of CSF1R (IC50 = 20nM) and c-KIT (IC50 = 10nM).1 Inhibition of CSF1R with Pexidartinib resulted in a reprogrammed immune microenvironment that fosters antitumor immunity in a CD8+ T-cell-dependent manner in a breast cancer model.1 CSF1R recruits tumor-infiltrating myeloid cell that suppress tumor immunity - Pexidartinib increased the efficacy of adoptive cell immunotherapy (ACT) in a mouse melanoma model by inhibiting the intratumoral accumulation of immunosuppressive macrophages.2,3 It has also been shown to increase the efficacy of anti-PD-14,5 and DC immunotherapy 6.