SR-717, CAS [[2375421-09-1]]

Produktübersicht

• Artikelname: SR-717, CAS [[2375421-09-1]]
• Artikelnummer: FBM-10-4850
• Hersteller Artikelnummer: 10-4850
• Alternativnummer: FBM-10-4850-10MG,FBM-10-4850-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

STING agonist

Produkteigenschaften

• Molekulargewicht: 381.27
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [2375421-09-1]
• Formel: C15H8F2N5O3Li

Anwendungsbeschreibung

• Anwendungsbeschreibung: Cell permeable and exceptionally selective STING agonist (IC50 = 7.8 µM). It displayed robust antitumor activity in B16.F10 melanoma and MC38 colorectal adenocarcinoma mouse models. SR-717 promoted the activation of CD8+ T, natural killer, and dendritic cells as well as promoting antigen cross-priming. It was able to induce PD-L1 expression in THP1 cells and in primary human PBMCs.