GSK2656157, CAS [[1337532-29-2]]

Produktübersicht

• Artikelname: GSK2656157, CAS [[1337532-29-2]]
• Artikelnummer: FBM-10-4855
• Hersteller Artikelnummer: 10-4855
• Alternativnummer: FBM-10-4855-5MG, FBM-10-4855-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-[5-(4-Amino-7-methylpyrrolo[2,3-d]pyrimidin-5-yl)-4-fluoro-2,3-dihydroindol-1-yl]-2-(6-methylpyridin-2-yl)ethanone

Produktbeschreibung

Potent and selective PERK inhibitor

Produkteigenschaften

• Molekulargewicht: 416.45
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1337532-29-2]
• Formel: C23H21FN6O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent (IC50 = 0.9 nM) and selective (over 300 kinases) inhibitor of protein kinase RNA-like endoplasmic reticulum kinase (PERK).1,2 Inhibited growth of multiple human tumor xenografts in mice. GSK2656157 has also been found to potently inhibit RIPK1 (IC50 = 69 nM) and TNF-mediated RIPK1 kinase-dependent cell death in mouse embryonic fibroblasts.3 It prevented the loss of dendritic spines and rescued memory deficits after traumatic brain injury.4 GSK2656157 also enhanced glucose-stimulated insulin secretion in a mouse model of type 2 diabetes mellitus.5