UCB9608, CAS [[1616413-96-7]]

Produktübersicht

• Artikelname: UCB9608, CAS [[1616413-96-7]]
• Artikelnummer: FBM-10-4857
• Hersteller Artikelnummer: 10-4857
• Alternativnummer: FBM-10-4857-5MG, FBM-10-4857-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (3S)-4-(6-Amino-1-methylpyrazolo[3,4-d]pyrimidin-4-yl)-N-(4-methoxy-2-methylphenyl)-3-methylpiperazine-1-carboxamide

Produktbeschreibung

Highly selective PI4KIIIß inhibitor

Produkteigenschaften

• Molekulargewicht: 410.48
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1616413-96-7]
• Formel: C20H26N8O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: UCB9608 is a potent (IC50 = 5 nM), highly selective, and orally bioavailable inhibitor of the phosphatidylinositol kinase PI4KIIIß.1 It acts as a potent immunosuppressive agent (IC50 = 37 nM human mixed lymphocyte reaction (HuMLR) assay) and was able to significantly prolong heterotopic allograft retention in a mouse model of cardiac allograft rejection. UCB9608 preserved graft tolerance in mice carrying a heterotopic allogenic heart challenged with host-type melanoma and subsequently treated with antitumor immunotherapy.2 UCB9608 promoted a T cell regulatory phenotype over an effector phenotype.3