Methylbenzoprim, CAS [[118344-71-1]]

Produktübersicht

• Artikelname: Methylbenzoprim, CAS [[118344-71-1]]
• Artikelnummer: FBM-10-4892
• Hersteller Artikelnummer: 10-4892
• Alternativnummer: FBM-10-4892-5MG, FBM-10-4892-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 5-[4-[Benzyl(methyl)amino]-3-nitrophenyl]-6-ethylpyrimidine-2,4-diamine. Alternate Names: Compound 19-S, NSC382035, MBP

Produktbeschreibung

Dual TYMS/DHFR inhibitor

Produkteigenschaften

• Molekulargewicht: 378.44
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Red/Orange solid
• CAS Nummer: [118344-71-1]
• Formel: C20H22N6O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Methylbenzoprim, a derivative of the antimalarial drug Pyrimethamine, is a non-classical potent inhibitor of mammalian dihydrofolate reductase (IC50 = 3.2 nM rat liver).1 It inhibited melanoma tumor growth both in vitro and in vivo.2 Methylbenzoprim has been recently found to also inhibit thymidylate synthase (TYMS) with activity comparable to the 5-FU metabolite FdUrd.3 It was more potent than 5-fluorouracil in a panel of 4 pancreatic ductal adenocarcinoma cells lines and without TYMS overexpression that frequently leads to drug resistance.3 Methylbenzoprim inhibited tumor growth and progression in two pancreatic cancer xenograft models. Orally bioavailable.