I2

Produktübersicht

• Artikelname: I2
• Artikelnummer: FBM-10-4908
• Hersteller Artikelnummer: 10-4908
• Alternativnummer: FBM-10-4908-5MG,FBM-10-4908-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

ERO1A inhibitor

Produkteigenschaften

• Molekulargewicht: 451.23
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Orange/red solid
• CAS Nummer: [Unknown]
• Formel: C21H11Cl2F3N2O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: I2 is an inhibitor of the oxidoreductase ERO1A (IC50 = 8.1 µM), a mediator of the unfolded protein response (UPR).1 Under cancer-related hypoxia conditions, ERO1A favors the folding of the angiogenic protein VEGFA leading to cancer cell growth and spread. I2 inhibited the metabolic activity of DMA-MB-231 triple negative breast cancer cells and impaired migration and VEGF secretion. Tumors in C57/BL6Jmice showed decreased levels of VEGF and PD-L1 when treated with I2.