PF-543 HCl, CAS [[1706522-79-3]]

Produktübersicht

• Artikelname: PF-543 HCl, CAS [[1706522-79-3]]
• Artikelnummer: FBM-10-4998
• Hersteller Artikelnummer: 10-4998
• Alternativnummer: FBM-10-4998-5MG, FBM-10-4998-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: [(2R)-1-[[4-[[3-(Benzenesulfonylmethyl)-5-methylphenoxy]methyl]phenyl]methyl]pyrrolidin-2-yl]methanol hydrochloride

Produktbeschreibung

Sphingosine kinase-1 inhibitor

Produkteigenschaften

• Molekulargewicht: 502.07
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [1706522-79-3]
• Formel: C27H31NO4SHCl

Anwendungsbeschreibung

• Anwendungsbeschreibung: PF-543 (1706522-79-3) is a potent (IC50 = 2.0 nM) and selective (>100-fold over SphK2) reversible inhibitor of sphingosine kinase-1 (SphK1).1 It induced autophagy in head and neck squamous cell carcinoma cells.2 PF-543 mitigated pulmonary fibrosis via reducing lung epithelial cell mitochondrial DNA damage and monocyte recruitment.3 It also alleviated sepsis-induced lung injury in an acute ethanol intoxication model in mice.4 PF-543 inhibited cell cycle and tumor growth in a xenograft model of non-small cell lung cancer.5