Osimertinib, CAS [[1421373-65-0]]

Produktübersicht

• Artikelname: Osimertinib, CAS [[1421373-65-0]]
• Artikelnummer: FBM-10-5036
• Hersteller Artikelnummer: 10-5036
• Alternativnummer: FBM-10-5036-10MG,FBM-10-5036-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: AZD-9291

Produktbeschreibung

Mutant EGFR kinase inhibitor

Produkteigenschaften

• Molekulargewicht: 499.62
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Pale-yellow solid
• CAS Nummer: [1421373-65-0]
• Formel: C28H33N7O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Osimertinib is a potent, selective, irreversible inhibitor of mutant EFGR tyrosine kinase.1 Osimertinib inhibits phosphorylation of EGFR in T790M-mutant cell lines (IC50 <15 nM) but was less potent at inhibition of EGFR phosphorylation in wild-type cells (IC50s in the range of 480 to 1,865 nM). It produces sustained tumor regression in EGFR-mutant tumor xenograft and transgenic rodent models.2 Tumor cells develop resistance to osimertinib but combination treatment with an IL-6 antibody reverses resistance to a certain extent.3 In clinical use for treatment of non-small cell lung cancer.4