Fludarabine, CAS [[21679-14-1]]

Produktübersicht

• Artikelname: Fludarabine, CAS [[21679-14-1]]
• Artikelnummer: FBM-10-5047
• Hersteller Artikelnummer: 10-5047
• Alternativnummer: FBM-10-5047-10MG,FBM-10-5047-50MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 9-beta-D-Arabinofuranosyl-2-fluoro-9H-purin-6-amine,. Alternate Names: F-ara-A, NSC118218

Produktbeschreibung

DNA synthesis inhibitor

Produkteigenschaften

• Molekulargewicht: 285.23
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [21679-14-1]
• Formel: C10H12FN5O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: A synthetic adenosine analog that inhibits DNA biosynthesis and is a clinically useful antineoplastic agent.1 In cells fludarabine accumulates as its 5-triphosphate (F-ara-ATP) for which the rate-limiting step in formation is the conversion of fludarabine to its monophosphate.2 F-ara-ATP has multiple mechanisms of action including inhibition of ribonucleotide reductase, DNA polymerase, ligase and primase.2 A frequently used agent in myeloablative conditioning regimens for allogeneic hematopoietic cell transplantation.3 Immunosuppressive effects are mediated via inhibition of TNF-stimulated production of IL-2 and IFN- through inactivation of NFB.4 Antagonist at adenosine A1 receptors.5

Bilder

10-5047