ICRF-193, CAS [[21416-88-6]]

Produktübersicht

• Artikelname: ICRF-193, CAS [[21416-88-6]]
• Artikelnummer: FBM-10-5056
• Hersteller Artikelnummer: 10-5056
• Alternativnummer: FBM-10-5056-1MG, FBM-10-5056-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: Meso-4,4-(2,3-butanediyl)-bis(2,6-piperazinedione)

Produktbeschreibung

Topoisomerase II inhibitor

Produkteigenschaften

• Molekulargewicht: 282.30
• Reinheit: >98% by TLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [21416-88-6]
• Formel: C12H18N4O4

Anwendungsbeschreibung

• Anwendungsbeschreibung: ICRF-193 is a topoisomerase II poison.1 Toposiomerase poisons are a special subclass of topoisomerase inhibitors that stabilize topoisomerase-DNA strand passing intermediates and thus cause the topoisomerases to become a cytotoxic DNA-damaging agent.1 It readily induces DNA strand breaks in V79 and irs-2 Chinese hamster lung fibroblasts via a novel mechanism.2 Displays cardioprotective (against anthracycline toxicity)3 and anti-inflammatory effects via reduction of IL-1beta secretion by macrophages4. An important tool for studying the cellular response to DNA double-strand breaks.5