Chemical Name: N-[(1S,3S,4S)-4-[[2-(2,6-Dimethylphenoxy)acetyl]amino]-3-hydroxy-5-phenyl-1-(phenylmethyl)pentyl]tetrahydro-alphaS-(1-methylethyl)-2-oxo-1(2H)-pyrimidineacetamide. Alternate Names: ABT-378, A-157378
HIV protease inhibitor
Molekulargewicht:
628.81
Reinheit:
>98% by HPLC NMR (Conforms)
Formulierung:
White solid
CAS Nummer:
[192725-17-0]
Formel:
C37H48N4O5
Anwendungsbeschreibung:
Lopinavir (192725-17-0) is a potent and selective inhibitor of HIV-1 protease (IC50 = 6.5 nM, HIV cultured in peripheral blood mononuclear cells, Ki = 1.3 pM) which is highly selective over mammalian proteases.1 Lopinavir suffers from poor bioavailability due to extensive cytochrome P450-mediated metabolism. Thus, combination with ritonavir suppresses metabolism and is a preferred regimen for treatment of HIV infection.2 Inhibits replication of SARS CoV-2 virus in vitro, IC50 = 26.63 µM.3
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