Ponatinib, CAS [[943319-70-8]]

Produktübersicht

• Artikelname: Ponatinib, CAS [[943319-70-8]]
• Artikelnummer: FBM-10-5064
• Hersteller Artikelnummer: 10-5064
• Alternativnummer: FBM-10-5064-5MG,FBM-10-5064-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: AP-24534

Produktbeschreibung

Bcr-Abl and multikinase inhibitor

Produkteigenschaften

• Molekulargewicht: 532.56
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Yellow solid
• CAS Nummer: [943319-70-8]
• Formel: C29H27F3N6O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Highly potent pan-Bcr-Abl and multikinase inhibitor, suppressing the activity of native Bcr-Abl (IC50=0.37 nM) as well as the mutants T315I (IC50=2 nM), Q252H (IC50=0.44 nM), Y253F (IC50=0.3 nM), M351T (IC50=0.3 nM) and H396P (IC50=0.34 nM).1 Also inhibits PDGFR, c-Src and c-Kit (IC50=1.1, 5.4 and 12.5 nM respectively)2 as well as FGFR-mediated signaling (IC50<40 nM)3. Protects against influenza A virus-induced death by suppressing cytokine storm in mouse models.4