PLX4720, CAS [[918505-84-7]]

Produktübersicht

• Artikelname: PLX4720, CAS [[918505-84-7]]
• Artikelnummer: FBM-10-5113
• Hersteller Artikelnummer: 10-5113
• Alternativnummer: FBM-10-5113-5MG,FBM-10-5113-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

Mutant B-Raf inhibitor

Produkteigenschaften

• Molekulargewicht: 413.82
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [918505-84-7]
• Formel: C17H14ClF2N3O3S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent and selective inhibitor of B-Raf, V600E mutant, IC50=13 nM (Wild type IC50=160 nM).1 It induces cell cycle arrest and apoptosis in B-RafV600E-positive cells and suppresses growth of B-RafV600E-positive xenografts.1 It induces tumor regression and reverses cachexia in a mouse model of human thyroid cancer harboring the B-RafV600E mutation.2 Early stage autophagy inhibitors and ER stress inhibition with 4-phenylbutyric acid increases the sensitivity of resistant cells to PLX4720.3 PLX4720 induces cytoprotective autophagy in thyroid cancer cells via AMPK-ULK1 pathway.4