DBIC, CAS [[487026-67-5]]

Produktübersicht

• Artikelname: DBIC, CAS [[487026-67-5]]
• Artikelnummer: FBM-10-5161
• Hersteller Artikelnummer: 10-5161
• Alternativnummer: FBM-10-5161-5MG,FBM-10-5161-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: (E)-N-(3,4-Dihydroxybenzylidene)-1H-benzo[d]imidazole-5-carbohydrazide

Produktbeschreibung

DNMT3B S-nitrosylation inhibitor

Produkteigenschaften

• Molekulargewicht: 296.29
• Reinheit: >98% by TLC NMR (Conforms)
• Formulierung: Grey solid
• CAS Nummer: [487026-67-5]
• Formel: C15H12N4O3

Anwendungsbeschreibung

• Anwendungsbeschreibung: Specifically inhibits S-nitrosylation of DNA methyltransferase 3B (DNMT3B) at low concentrations, IC50100 nM, without affecting its enzymatic activity. Treatment with DBIC prevents nitric oxide-induced conversion of human colonic adenoma to adenocarcinoma in vitro. Treatment with DBIC strongly attenuates tumor development in a mouse model of carcinogenesis triggered by inflammation-induced NO production. DNMT3B-mediated DNA methylation is regulated by S-nitrosylaton and DBIC represents a new useful tool for studying this system.1 A negative control compound, DBIC-neg2 (Cat 10-5162) is also available.

Bilder

10-5161