CEP (1838570-66-3) is a clickable electrophilic purine which may be used to directly quantify protein-RNA interaction on proteins via photoaffinity competition with 4-thiouridine-labeled RNA in cells. Employing CEP in a photo-activatable-competition and chemoproteomic enrichment (PACCE) protocol enables functional profiling of canonical RNA-binding domains as well as the discovery of ''moonlighting RNA binding activity in the human proteome. This new methodology represents a chemoproteomic platform for global quantification of protein-RNA binding activity in living cells.
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