CDDO-Me, CAS [[218600-53-4]]

Produktübersicht

• Artikelname: CDDO-Me, CAS [[218600-53-4]]
• Artikelnummer: FBM-10-5449
• Hersteller Artikelnummer: 10-5449
• Alternativnummer: FBM-10-5449-5MG,FBM-10-5449-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Bardoxolone methyl, RTA 402, TP-155, CDDO-Methyl ester

Produktbeschreibung

Nrf2 activator

Produkteigenschaften

• Molekulargewicht: 505.70
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [218600-53-4]
• Formel: C32H43NO4

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent activator of Nrf2 target transcription via interaction with thiol groups of Keap1, an Nrf2 partner, in phase 2 response against oxidative stress.1 Inhibits the NF-kappaB pathway via inhibition of IKKalpha activation in vitro2 and reduces expression of proinflammatory cytokines in vivo3. Alters tumor microenvironment causing breast tumor associated macrophages to switch from tumor-promoting to tumor-inhibiting characteristics in vitro.4 Reduces cancer stem cell marker expression in Ec109 and KYSE70 cells.5