Pyridone 6, CAS [[457081-03-7]]

Produktübersicht

• Artikelname: Pyridone 6, CAS [[457081-03-7]]
• Artikelnummer: FBM-10-5555
• Hersteller Artikelnummer: 10-5555
• Alternativnummer: FBM-10-5555-1MG, FBM-10-5555-5MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-(tert-Butyl)-9-fluoro-1Hbenzo[h]imidazo[4,5-f]isoquinolin-7(6H)-one. Alternate Names: JAK Inhibitor I

Produktbeschreibung

pan-JAK inhibitor

Produkteigenschaften

• Molekulargewicht: 309.34
• Reinheit: 98% by HPLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [457081-03-7]
• Formel: C18H16FN3O

Anwendungsbeschreibung

• Anwendungsbeschreibung: Potent, ATP-competitive pan-JAK inhibitor. Inhibits 1, 2 and 3 (IC50=1, 5 and 15 nM respectively) as well as JAK family member Tyk2 (IC50=1 nM).1 Also tested against 21 other kinases with inhibition ranging from 130 nm to >10 mM. Inhibits IL2 and IL4-dependent proliferation of CTLL cells.1 Induces intermediate mesoderm differentiation from embryonic stem cells in a cocktail with LY-294002, CCG-1423 and retinoic acid.2 Potently inhibits STAT1, STAT5 and STAT6 phosphorylation and ameliorates allergic skin inflammation in a mouse model.3 Suppresses asthmatic responses in a mouse allergic asthma model.4