TPCA-1, CAS [[507475-17-4]]

Produktübersicht

• Artikelname: TPCA-1, CAS [[507475-17-4]]
• Artikelnummer: FBM-10-5571
• Hersteller Artikelnummer: 10-5571
• Alternativnummer: FBM-10-5571-5MG, FBM-10-5571-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 2-[(Aminocarbonyl)amino]-5-(4-fluorophenyl)-3-thiophenecarboxamide

Produktbeschreibung

Selective inhibitor of IkappaB kinase 2 (IKK2)

Produkteigenschaften

• Molekulargewicht: 229.29
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: Pale yellow solid
• CAS Nummer: [507475-17-4]
• Formel: C12H10FN3O4S

Anwendungsbeschreibung

• Anwendungsbeschreibung: Selective inhibitor of IkappaB kinase 2 (IKK2) (IC50 = 17.9 nM).1 Inhibits production of pro-inflammatory cytokines in arthritis and other animal models of inflammation.1,2 Also attenuates NLRP3 inflammasome activation in THP-1 myeloid cells, and suppresses IL1beta-induced proliferation, migration, and invasion of HeLa cells.3,4 Continuous exposure to TPCA-1 promotes expansion of hematopoietic stem/progenitor cells (HSPCs) via improved glycolysis and limited ROS production.5