BMH-21, CAS [[896705-16-1]]

Produktübersicht

• Artikelname: BMH-21, CAS [[896705-16-1]]
• Artikelnummer: FBM-10-5688
• Hersteller Artikelnummer: 10-5688
• Alternativnummer: FBM-10-5688-5MG, FBM-10-5688-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-[2-(Dimethylamino)ethyl]-12-oxo-12H-benzo[g]pyrido[2,1-b]quinazoline-4-carboxamide

Produktbeschreibung

RNA polymerase I inhibitor

Produkteigenschaften

• Molekulargewicht: 360.42
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Orange solid
• CAS Nummer: [896705-16-1]
• Formel: C21H20N4O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: A planar heterocyclic DNA intercalator that inhibits RNA polymerase I (Pol I), IC50 = 0.6 µM in U2OS cells, but not Pols II or III, blocking transcription elongation without inducing the DNA damage response.1-3 Inhibition disengages Pol I from chromatin, resulting in proteasome-dependent destruction of Pol I subunit RPA194.4 At nanomolar concentrations it also activates p53 in A375 cells.5