SU9516, CAS [[377090-84-1]]

Produktübersicht

• Artikelname: SU9516, CAS [[377090-84-1]]
• Artikelnummer: FBM-10-5705
• Hersteller Artikelnummer: 10-5705
• Alternativnummer: FBM-10-5705-5MG,FBM-10-5705-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien

Produktbeschreibung

CDK inhibitor (pan-specific)

Produkteigenschaften

• Molekulargewicht: 241.25
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: Orange solid
• CAS Nummer: [377090-84-1]
• Formel: C13H11N3O2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Cyclin-dependent kinase inhibitor, IC50s= 0.02-0.03, 0.04-0.2, 0.2-1.7 and 0.9 µM for cdk2, cdk1, cdk4, cdk9 respectively.1,2 Inhibits phosphorylation of retinoblastoma protein pRb, causing enhanced pRb/E2f complex formation, cell cycle arrest at G1 and G2-M and apoptosis.3 Down-regulates antiapoptotic protein Mcl-1 expression resulting in mitochondrial injury and cell death.4 Inhibits epithelial-mesenchymal transition (IC50=1.21 µM) a crucial pathological event in tumor cell budding and metastasis.5 Cell permeable.