M22, CAS [[864420-54-2]]

Produktübersicht

• Artikelname: M22, CAS [[864420-54-2]]
• Artikelnummer: FBM-10-5733
• Hersteller Artikelnummer: 10-5733
• Alternativnummer: FBM-10-5733-5MG, FBM-10-5733-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-Benzyl-N-(2,4-dichlorophenethyl) piperidin-4-amine. Alternate Names: NAE-IN-M22, N-[2-(2,4-dichlorophenyl)ethyl]-1-(phenylmethyl)-4-piperidinamine

Produktbeschreibung

NEDD8 activating enzyme inhibitor

Produkteigenschaften

• Molekulargewicht: 363.33
• Reinheit: >98% by TLC NMR (Conforms)
• Formulierung: Off-white solid
• CAS Nummer: [864420-54-2]
• Formel: C20H24Cl2N2

Anwendungsbeschreibung

• Anwendungsbeschreibung: Protein neddylation is a post-translational modification which transfers the ubiquitin-like protein NEDD8 to a lysine residue of the target substrate through a three-step enzymatic cascade and has been considered as a viable target for the development of new therapeutics for cancer.1 M22 (CAS 864420-54-2) is an inhibitor of NEDD8 activating enzyme (NAE) which was discovered by virtual screening of a small molecule library (50,000 compounds) against the active site of NAE.2 M22 is selective and reversible and inhibits NEDDylation of ubiquitin-conjugating enzyme 12 (UBC12) in a cell-free assay employing recombinant human NAE. It selectively inhibits NEDDylation over SUMOylation and ubiquitination in A549 cells and inhibits their growth (GI50 = 5.5 µM). It has been shown to inhibit tumor growth in a mouse xenograft model (at 60 mg/kg).2