SBI-797812, CAS [[2237268-08-3]]

Produktübersicht

• Artikelname: SBI-797812, CAS [[2237268-08-3]]
• Artikelnummer: FBM-10-5778
• Hersteller Artikelnummer: 10-5778
• Alternativnummer: FBM-10-5778-5MG, FBM-10-5778-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: N-[4-(8-Oxa-3-azabicyclo[3.2.1]oct-3-ylsulfonyl)phenyl]-N'-(4-pyridinylmethyl)-urea

Produktbeschreibung

NAMPT activator

Produkteigenschaften

• Molekulargewicht: 402.47
• Reinheit: >98% by HPLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [2237268-08-3]
• Formel: C19H22N4O4S

Anwendungsbeschreibung

• Anwendungsbeschreibung: NAMPT is the rate-limiting enzyme in the nicotinamide adenine dinucleotide (NAD+) salvage pathway that converts nicotinamide to nicotinamide mononucleotide (NMN) which is responsible for most of the NAD+ formation in mammals.1 Cellular levels of NAD+ have been shown to decrease with age and NAMPT is believed to be a key enzyme in the aging/senescence process.2 SBI-797812 is a NAMPT activator, turning it into a ''super catalyst that more efficiently generates NMN.3 It increases NMN levels and prevents NAD+ feedback inhibition in a cell-free assay using recombinant human NAMPT at a concentration of 2 µM. In mice (20 mg/kg), it increases liver levels of NAD+ and shows a trend toward increased levels in cardiac tissue but does not affect levels in the quadriceps, or gastrocnemius.3