JNJ-3792165, CAS [[353504-63-9]]

Produktübersicht

• Artikelname: JNJ-3792165, CAS [[353504-63-9]]
• Artikelnummer: FBM-10-5863
• Hersteller Artikelnummer: 10-5863
• Alternativnummer: FBM-10-5863-5MG,FBM-10-5863-25MG
• Hersteller: Focus Biomolecules
• Kategorie: Biochemikalien
• Alternative Synonym: Chemical Name: 1-(2,6-Dichlorobenzyl)-5-methyl-N-(m-tolyl)-1H-pyrazole-3-carboxamide

Produktbeschreibung

GPR139 antagonist

Produkteigenschaften

• Molekulargewicht: 374.27
• Reinheit: 98% by TLC NMR (Conforms)
• Formulierung: White solid
• CAS Nummer: [353504-63-9]
• Formel: C19H17Cl2 N3O

Anwendungsbeschreibung

• Anwendungsbeschreibung: JNJ-3792165 is a potent and selective antagonist at GPR139, a non-canonical opioid receptor. It has high affinity for human GPR139 (pKi = 7.7, displacement of [3H] JNJ-6353054) and behaves as an antagonist in a [35S]GTPgammaS assay (pKb = 7.4) and calcium mobilization assay.1 It displayed no significant affinity in a selectivity screen of over 50 other neurotransmitter and neuropeptide receptors (less than 50% inhibition at 1 µM).1 Completely blocks (10 mM) the effects of optogenetic stimulation of dynorphin release in dynorphinergic neurons of the nucleus accumbens at 10 mM.2 JNJ-3792165 is an important new tool for exploring the biology of GPR139.3,4

Bilder

10-5863