This antimicrobial gene encodes a chemokine of the CXC subfamily and ligand for the receptor CXCR3. Binding of this protein to CXCR3 results in pleiotropic effects, including stimulation of monocytes, natural killer and T-cell migration, and modulation o
Reconstitute with 20mM Tris (pH8.0) and 150mM NaCl (pH8.0) to 0.1-1.0mg/ml. Do not vortex. Lyophilized from 20mM Tris (pH8.0), 150mM NaCl, 1mM EDTA, 1mM DTT, 0.01% SKL, 5% Trehalose, ProClin 300.
Expression System:
E. coli
Formulierung:
Lyophilized powder
Sequenz:
N-terminal His-Tag, Val22~Pro98 (NP_001556.2)
Anwendungsbeschreibung:
Interferon gamma-induced protein 10 (IP10) also known as C-X-C motif chemokine 10 (CXCL10) or small-inducible cytokine B10 is an 8. 7kDa protein that in humans is encoded by the CXCL10 gene. C-X-C motif chemokine 10 is a small cytokine belonging to the C
GTX00242-pro Image
Functional ELISA analysis of GTX00242-pro Human CXCL10 / IP10 protein (active) which can bind immobilized IGFBP7 protein.
The chemotactic effect of GTX00242-pro Human CXCL10 / IP10 protein (active). Upper: (A) Raji cells were seeded into the upper chambers and serum free RPMI-1640 without IP10 was added in lower chamber, then cells in lower chamber were observed at low magnification (×100) after incubation for 2hrs. (B) Raji cells were seeded into the upper chambers and serum free RPMI-1640 with 10 ng/ml IP10 was added in lower chamber, then cells in lower chamber were observed at low magnification (×100) after incubation for 1hr. Lower: The number of migrated cells were counted at high magnification (×400) randomly (five fields for each filter).
SDS-PAGE analysis of GTX00242-pro Human CXCL10 / IP10 protein (active).
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