CD11b antibody [ICRF44], IgG1, Unconjugated, Mouse, Monoclonal

Produktübersicht

• Artikelname: CD11b antibody [ICRF44], IgG1, Unconjugated, Mouse, Monoclonal
• Artikelnummer: GTX00481
• Hersteller Artikelnummer: GTX00481
• Alternativnummer: GTX00481-100
• Hersteller: GeneTex
• Wirt: Mouse
• Kategorie: Antikörper
• Applikation: Activation, FC, ICC, IHC-Fr, IP, NeA, WB
• Spezies Reaktivität: Human, Porcine, Primate
• Immunogen: Rheumatoid synovial cells and human monocytes.
• Konjugation: Unconjugated
• Alternative Synonym: integrin subunit alpha M , CD11B , CR3A , MAC-1 , MAC1A , MO1A , SLEB6

Produktbeschreibung

The ICRF44 antibody reacts with human CD11b, also known as integrin alphaalpha M. This 165-170 kDa cell surface glycoprotein is part of a family of integrin alphareceptors that mediate adhesion between cells (cell-cell) and components of the extracellular matrix, e.g. fibrinogen (cell-matrix). In addition, integrin alphas are active signaling receptors which recruit leukocytes to inflammatory sites and promote cell activation. Complete, functional integrin alphareceptors consist of distinct combinations of integrin alphachains which are differentially expressed. integrin alphaalpha M (CD11b) assembles with integrin alphabeta-2 (CD18) into a receptor known as Macrophage Antigen-1 (Mac-1) or complement receptor type 3 (CR3). This receptor binds and induces intracellular signaling through ICAM-1, ICAM-2, ICAM-3 and ICAM-4 on endothelial cells and can also facilitate removal of iC3b bearing foreign cells.

Produkteigenschaften

• Klonalität: Monoclonal
• Konzentration: 0.5 mg/ml (Please refer to the vial label for the specific concentration.)
• Klon-Bezeichnung: [ICRF44]
• Molekulargewicht: 127
• Isotyp: IgG1
• NCBI: 3684
• UniProt: P11215
• Puffer: 10mM NaH2PO4, 150mM NaCl, 0.09% Sodium azide.
• Reinheit: Purified by affinity chromatography
• Formulierung: Liquid