CD3 epsilon antibody [145-2C11] (Biotin), IgG1, Hamster, Monoclonal
Artikelnummer:
GTX00603-02
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| Artikelname: | CD3 epsilon antibody [145-2C11] (Biotin), IgG1, Hamster, Monoclonal |
| Artikelnummer: | GTX00603-02 |
| Hersteller Artikelnummer: | GTX00603-02 |
| Alternativnummer: | GTX00603-02-100 |
| Hersteller: | GeneTex |
| Wirt: | Hamster |
| Kategorie: | Antikörper |
| Applikation: | FC |
| Spezies Reaktivität: | Mouse |
| Immunogen: | Mouse BM10-37 cytotoxic T lymphocytes |
| Konjugation: | Biotin |
| Alternative Synonym: | CD3 antigen, epsilon polypeptide , AI504783 , CD3 , CD3epsilon , T3e |
| The 145-2C11 antibody is specific for mouse CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor - CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. Such interactions promote T cell receptor signaling (T cell activation) and can result in a number of cellular responses including proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells. |
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