CD3 antibody [Hit3a], IgG2a, Unconjugated, Mouse, Monoclonal
Artikelnummer:
GTX01459
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| Artikelname: | CD3 antibody [Hit3a], IgG2a, Unconjugated, Mouse, Monoclonal |
| Artikelnummer: | GTX01459 |
| Hersteller Artikelnummer: | GTX01459 |
| Alternativnummer: | GTX01459-100 |
| Hersteller: | GeneTex |
| Wirt: | Mouse |
| Kategorie: | Antikörper |
| Applikation: | Activation, FC, ICC, IHC-Fr, NeA |
| Spezies Reaktivität: | Human, Primate |
| Konjugation: | Unconjugated |
| Alternative Synonym: | CD3d molecule , CD3e molecule , CD3g molecule , CD247 molecule , CD3-DELTA , IMD19 , T3D , IMD18 , T3E , TCRE , CD3-GAMMA , IMD17 , T3G , CD3-ZETA , CD3H , CD3Q , CD3Z , IMD25 , T3Z , TCRZ |
| The Hit3a antibody is specific for human CD3e, also known as CD3 epsilon, a 20 kDa subunit of the T cell receptor complex, along with CD3 gamma and CD3 delta. These integral membrane protein chains assemble with additional chains of the T cell receptor (TCR), as well as CD3 zeta chain, to form the T cell receptor - CD3 complex. Together with co-receptors CD4 or CD8, the complex serves to recognize antigens bound to MHC molecules on antigen-presenting cells. These interactions promote T cell receptor signaling (T cell activation), inducing cell proliferation, differentiation, production of cytokines or activation-induced cell death. CD3 is differentially expressed during thymocyte-to-T cell development and on all mature T cells.The Hit3a antibody is a widely used phenotypic marker for human T cells. In addition, binding/cross-linking of Hit3a antibody to CD3e can induce cell activation. The antibody has also been demonstrated to be cross-reactive with Chimpanzee CD3. |
| Anwendungsbeschreibung: | *Optimal dilutions/concentrations should be determined by the researcher.Not tested in other applications. |
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