IL2 Receptor alpha antibody [PC61.5] (PE), IgG1, Rat, Monoclonal
Artikelnummer:
GTX01472-08
Hersteller Artikelnummer:
GTX01472-08
Alternativnummer:
GTX01472-08-100
Hersteller:
GeneTex
Wirt:
Rat
Kategorie:
Antikörper
Applikation:
FC
Spezies Reaktivität:
Mouse
Konjugation:
PE
The PC61.5 antibody is specific for mouse CD25, a 55 kDa surface protein also known as the Interleukin-2 Receptor alpha chain, or IL-2R alpha. CD25 may bind IL-2 by itself, although with low affinity and without induction of cell signaling. CD25 is also expressed within a high-affinity complex, along with the IL-2R beta chain (CD122) and the common gamma chain (CD132), to form a signaling receptor complex. Expression of CD25 varies during developmental stages of T and B cells, is induced on activated mature T and B cells, and is present on subsets of dendritic cells. CD25 signaling as part of the IL-2 receptor complex triggers T cell activation and proliferation, as well as modulating the differentiation and function of Th17 cells, T regulatory (Treg) cells, and dendritic cells. The PC61.5 antibody is used as a marker for T cells, B cells and dendritic cell subsets. Expression of CD25, CD4 and the transcription factor Foxp3 is regarded as a phenotypic signature for Treg cells. As such, this antibody is widely used to distinguish Treg cells from naive or conventional T cells which are CD25. This clone has also been reported for depletion of Treg cells in vivo.
Klonalität:
Monoclonal
Konzentration:
0.2 mg/ml (Please refer to the vial label for the specific concentration.)
