RGDS peptide is a tetrapeptide found on fibronectin, fibrinogen alpha, and von Willebrand factor, but not vitronectin or collagen. RGDS interacts with alpha5beta1 and alphaVbeta3 integrins and interferes with the attachment of cells to fibronectin coated surfaces and also blocks the attachment of pathogens to cells. The interaction of RGDS peptide with cell surface integrins alters intracellular signaling in a cell and stimulus specific manner.
