A 769662 is a potent and reversible AMP-activated protein kinase (AMPK) allosteric activator with an EC50 of 0.8 µM, that displays selectivity towards beta1 subunit-containing heterotrimers, activating AMPK by binding to the beta and i subunits and not the AMP binding site. AMPK is a key cellular energy sensor and regulator of metabolic homeostasis and activation of AMPK provides beneficial outcomes in fighting against metabolic disorders such as insulin resistance and type 2 diabetes. In vivo, A 769662 inhibits fatty acid biosynthesis in rat hepatocytes and decreases plasma glucose and triglyceride levels. In ob/ob mice, A-769662 inhibits the rate of whole-body fatty acid oxidation, decreases body weight gain, reduces triglycerides and lowers glucose levels. A 769662 also inhibits proliferation of mesenchymal stem cells and impedes reprogramming of mouse embryonic fibroblasts to induced pluripotent stem cells (iPSCs).
Molekulargewicht:
360.39
Reinheit:
98% by HPLC, NMR conforms
Formulierung:
White solid
CAS Nummer:
[844499-71-4]
Formel:
C20H12N2O3S
Target-Kategorie:
Kinases
Anwendungsbeschreibung:
ProductType: Small molecules
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