i-2 is a trimeric lipopeptoid with antifungal activity against Cryptococcus neoformans and minimal mammalian cell toxicity. i-2 is an optimized derivation of AEC5 and has improved potency towards C. neoformans and decreased toxicity towards NIH/3T3 mouse fibroblasts, with a selectivity ratio improved from 8 for AEC5 to 21 for i-2.
