DAPT is a i-secretase inhibitor, which can reduce Abeta40 and Abeta42 levels in human primary neuronal cultures with IC50 values of 115 and 200 nM for total Abeta and Abeta42 respectively. DAPT is also active also in brain extract, cerebrospinal fluid and plasma in vivo, with no no effect on APPalpha and APPbeta levels. DAPT blocks notch signaling in hybrid human-mouse fetal thymus organ culture (FTOC) and can cause causes embryonic stem cells (ESCs) to commit to neuronal differentiation. DAPT can be used in a small molecule cocktail to derive cortical neurons from human pluripotent stem cells (hPSCs) and maintain hepatocytes in culture. DAPT also promotes the formation of cone photoreceptors in retinal organoids.
Molekulargewicht:
432.46
Reinheit:
98% by TLC, NMR conforms
Formulierung:
White solid
CAS Nummer:
[208255-80-5]
Formel:
C23H26F2N2O4
Target-Kategorie:
Secretases
Anwendungsbeschreibung:
ProductType: Small molecules
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