mRNA Cap 2-O-Methyltransferase, GMP-Grade (GMP-MEH-VE101), DMF 038029 - Preis auf Anfrage

Produktübersicht

• Artikelname: mRNA Cap 2-O-Methyltransferase, GMP-Grade (GMP-MEH-VE101), DMF 038029 - Preis auf Anfrage
• Artikelnummer: KAB-GMP-MEH-VE101
• Hersteller Artikelnummer: GMP-MEH-VE101
• Alternativnummer: KAB-GMP-MEH-VE101-50KU, KAB-GMP-MEH-VE101-5MU
• Hersteller: KactusBio
• Kategorie: Molekularbiologie

Produktbeschreibung

mRNA Cap 2-O-Methyltransferase, utilizing S-adenosylmethionine (SAM) as a methyl group donor, adds a methyl group at the 2-O position of the first nucleotide adjacent to the Cap0 structure at the 5 end of RNA to obtain m7Gppp5mN Cap1 structure. Cap1 structure is a signature of self RNA.and has been shown to modulate binding of innate immune sensors. For instance, the binding affinity of IFIT-1 for Cap1 is much weaker than for 5 triphosphate or Cap0 structure, Cap1 structure abrogates RIG-1 signaling and prevents detection by MDA5. NOTE: Vaccinia Capping Enzyme GMP-VCS-VE101) is required to generate Cap0 structure. This product has been filed with the FDA Drug Master Files (DMF) and is assigned DMF 038029.

Produkteigenschaften

• Puffer: Liquid

Bilder

Figure 1. Analysis of mRNA capping efficiency using LC-MS.