Peretinoin is an oral acyclic retinoid with a vitamin A-like structure that targets retinoid nuclear receptors such as retinoid X receptor (RXR) and retinoic acid receptor (RAR). Peretinoin reduces the mRNA level of sphingosine kinase 1 (SPHK1) in vitro by downregulating a transcription factor, Sp1[1]. Peretinoin prevents the progression of non-alcoholic steatohepatitis (NASH) and the development of hepatocellular carcinoma (HCC) through activating the autophagy pathway by increased Atg16L1 expression[2]. Peretinoin inhibits HCV RNA amplification and virus release by altering lipid metabolism with a EC50 of 9 µM[3].
Molekulargewicht:
302.45
Reinheit:
99.79
CAS Nummer:
[81485-25-8]
Formel:
C20H30O2
Target-Kategorie:
Autophagy,HCV,RAR/RXR,SphK
Anwendungsbeschreibung:
Reference compound
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