BAY-876, a chemical probe, is an orally active and selective glucose transporter 1 (GLUT1) inhibitor with an IC50 of 2 nM. BAY-876 is >130-fold more selective for GLUT1 than GLUT2, GLUT3, and GLUT4. BAY-876 is also a potent blocker of glycolytic metabolism and ovarian cancer growth. In addition, BAY-876 can induce the formation of disulfide bonds in actin cytoskeletal proteins, leading to the occurrence of cellular disulfidptosis[1][2][3].
Molekulargewicht:
496.42
Reinheit:
99.67
CAS Nummer:
[1799753-84-6]
Formel:
C24H16F4N6O2
Target-Kategorie:
Disulfidptosis,GLUT
Anwendungsbeschreibung:
MCE Product type: Reference compound
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