BMY 28674, CAS [[125481-61-0]]

Produktübersicht

• Artikelname: BMY 28674, CAS [[125481-61-0]]
• Artikelnummer: MCE-HY-100057
• Hersteller Artikelnummer: HY-100057
• Alternativnummer: MCE-HY-100057-1MG
• Hersteller: MedchemExpress
• Kategorie: Biochemikalien
• Alternative Synonym: 6-Hydroxybuspirone, 6-Hydroxybuspirone, BMS 528215

Produktbeschreibung

BMY 28674 (6-Hydroxybuspirone) is the active metabolite of the anxiolytic buspirone (HY-B1115A) and is metabolized by CYP3A4.4. BMY 28674 binds to the serotonin (5-HT) receptor subtype 5-HT1A in the rat hippocampus and dorsal raphe (EC50s are 4 and 1 µM, respectively) and is an antagonist of dopamine D2, D3, and D4 receptors (IC50s are 3.1, 4.9, and 0.85 µM, respectively). BMY 28674 also inhibits organic cation transporter 1 (OCT1), OCT2, and OCT3 expressing human transporters in S2 proximal tubule cells in a concentration-dependent manner.

Produkteigenschaften

• Molekulargewicht: 401.50
• CAS Nummer: [125481-61-0]
• Formel: C21H31N5O3
• Target-Kategorie: 5-HT Receptor,Dopamine Receptor,Drug Metabolite

Anwendungsbeschreibung

• Anwendungsbeschreibung: MCE Product type: Reference compound