Zenidolol (ICI-118551) is a selective beta2-adrenergic receptor antagonist with Ki values of Zenidolol for beta2, beta1 and beta3 adrenergic receptors of 0.7, 49.5 and 611 nM, respectively. Zenidolol exerts antitumor effects via inducing apoptosis, inhibiting tumor sphere formation, and downregulating the HIF pathway by blocking beta2-AR on tumor cells. Zenidolol exhibits a unique pulmonary vessel-specific vasodilatory effect in mouse models. Zenidolol can be used as an intraocular pressure-lowering agent in ophthalmic disease research[1][2][3][4][5].
